pI: 10.2904 |
Length (AA): 222 |
MW (Da): 24861 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | ME49 Tachyzoite. | Gregory |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite, ME49 Oocyst. | Gregory Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 Bradyzoite. | Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 merozoite. | Hehl AB |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_129299)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G51840 | acyl-coenzyme A oxidase 4 |
Caenorhabditis elegans | CELE_F54D5.7 | Protein F54D5.7 |
Dictyostelium discoideum | DDB_G0283411 | glutaryl-CoA dehydrogenase |
Dictyostelium discoideum | DDB_G0274585 | hypothetical protein |
Drosophila melanogaster | Dmel_CG9547 | CG9547 gene product from transcript CG9547-RA |
Homo sapiens | ENSG00000105607 | glutaryl-CoA dehydrogenase |
Mus musculus | ENSMUSG00000003809 | glutaryl-Coenzyme A dehydrogenase |
Mycobacterium tuberculosis | Rv0400c | Acyl-CoA dehydrogenase FadE7 |
Mycobacterium ulcerans | MUL_2825 | acyl-CoA dehydrogenase FadE7 |
Oryza sativa | 4324062 | Os01g0159400 |
Oryza sativa | 4337904 | Os05g0163700 |
Schmidtea mediterranea | mk4.008512.01 | |
Schmidtea mediterranea | mk4.008440.00 | |
Schmidtea mediterranea | mk4.002644.03 | Glutaryl-CoA dehydrogenase, mitochondrial |
Schmidtea mediterranea | mk4.022596.00 | |
Schmidtea mediterranea | mk4.035706.00 | Probable glutaryl-CoA dehydrogenase, mitochondrial |
Trypanosoma cruzi | TcCLB.510121.40 | hypothetical protein |
Trypanosoma cruzi | TcCLB.508951.40 | acyl-CoA dehydrogenase, putative |
Toxoplasma gondii | TGME49_214400 | hypothetical protein |
Toxoplasma gondii | TGME49_231900 | acyl-CoA dehydrogenase domain-containing protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu403 | Mycobacterium tuberculosis | essential | nmpdr |
TGME49_214400 this record | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_231900 | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.